一、个人简介
房耀维，男，博士，三级教授，研究生导师，科学技术处副处长。江苏省“333高层次人才培养工程”培养对象，江苏省“六大人才高峰”高层次人才，江苏省“青蓝工程”优秀青年骨干教师培养对象。主持国家自然科学基金面上项目等科研项目20余项。获得江苏省科技进步奖三等奖、中国轻工业联合会科学技术发明奖三等奖、江苏省轻工业科学技术奖励技术发明奖一等奖、江苏省轻工业科学技术奖励技术发明奖三等奖各1项。指导研究生获得江苏省优秀硕士学位论文1篇。主要研究方向为1）生物转化：食品活性物如海洋活性肽、低聚糖、植物多酚的微生物转化及活性评价等；2）益生菌开发，功能性益生菌的筛选及作用机制研究；3）食品酶工程：酶的发掘、性质、结构解析、分子改造等。相关研究在Trends in Food Science＆Technology、Current Opinion in Food Science、Journal of Agricultural and Food Chemistry等期刊发表论文150余篇，SCI收录80余篇。授权国家发明专利20余件；参与出版专著1部。
联系电话：15861240818；E-Mail:foroei@163.com
二、近5年代表性论文
[1]Hua Z, Wu Q, Yang Y, Liu S, Tchuere GJ, Danyue Z*, YFang Y*. Essential roles of ellagic acid-to-urolithin converting bacteria in human health and health food industry: An updated review.Trends in Food Science & Technology. 2024, 151: 104622 (SCI 1区, IF 15.1).
[2]Xia M, Hua Z, Zhao Y, Zhang G, Hou X, Yang G, Liu S,Fang Y*. Improvement of urolithin A yield by in vitro co-fermentation ofStreptococcus thermophilusFUA329 with human gut microbiota from different urolithin metabotypes. J Agric Food Chem. 2024, 72(6):3008-3016. (SCI 1区, IF 6.1).
[3]He F, Bian Y, Zhao Y, Xia M, Liu S, Gui J, Hou X*,Fang Y*. In vitro conversion of ellagic acid to urolithin A by different gut microbiota of urolithin metabotype A. Appl Microbiol Biotechnol. 2024, 108(1): 215. (SCI 3区, IF 3.9).
[4]Yang G, Hu Z, Wang Y, Mo H, Liu S, Hou X, Wu X, Jiang H,Fang Y*. Engineering chitin deacetylase AsCDA for improving the catalytic efficiency towards crystalline chitin. Carbohydrate Polymers. 2023, 318: 121123. (SCI 1区, IF11.2).
[5]Hou X, Li M, Mao C, Jiang L, Zhang W, Li M, Geng X, Li X, Liu S, Yang G, Zhou J,Fang Y*, Cai J*. Domain III β4–β5 Loop and β14–β15 Loop ofBacillus thuringiensisVip3Aa are involved in receptor binding and toxicity. Toxins (Basel). 2024, 16(1):23. (SCI 3区, IF4.2)
[6]Liu Q, Bian Y, Mu S, Chen M, Liu S, Yang G, Huang Y, Hou X*,Fang Y*. Genomic and phenotypic-based safety assessment and probiotic properties ofStreptococcus thermophilusFUA329, a urolithin A-producing bacterium of human milk origin. Genomics. 2023,115(6):110724. (SCI 2区, IF4.4)
[7]Liu Q, Hua Z, Chen M, Liu S, Sibtain A, Hou Xe, Yang G,FangY*. Changes in Polyphenols and Antioxidant Properties of Pomegranate Peels Fermented by Urolithin A-ProducingStreptococcus thermophilusFUA329. ACS Food Science & Technology. 2023,3(8): 1383-1392. (SCI 2区，IF2.6).
[8]Liu Q, Liu S, Ye Q, Hou X, Yang G, Lu J, Hai Y，Shen J，Fang Y*. ANovelStreptococcus thermophilusFUA329 isolated from Human breast milk capable of producing Urolithin A from ellagic acid. Foods. 2022, 11, 3280. (SCI 2区, IF 5.561).
[9]Yang G, Hou X, Lu J, Wang M, Wang Y, Huang Y, Liu Q, Liu S*,Fang Y*.Enzymatic modification of native chitin and chitin oligosaccharides by an alkaline chitin deacetylase fromMicrobacterium esteraromaticumMCDA02. International Journal of Biological Macromolecules. 2022, 203:671-678. (SCI 1区, IF 6.625)
[10]Mi H, Liu S, Hai Y, Yang G, Lu J, He F, Zhao Y, Xia M, Hou X*,Fang Y*.LactococcusgarvieaeFUA009, a novel intestinal bacterium capable of producing the bioactive metabolite urolithin A from ellagic acid. Foods. 2022, 11(17):2621 (SCI 2区, IF 5.561).
[11]Ding Z, Ahmed S, Hang J, Mi H, Hou X, Yang G, Huang Z, Lu X, Zhang W, Liu S,Fang Y*.Rationally engineered chitin deacetylase from Arthrobacter sp. AW19M34-1 with improved catalytic activity toward crystalline chitin.Carbohydrate Polymers. 2021, 274: 118637. (SCI 1区, IF 10.723).
[12]Yang G, Cui X, Liu S, Lu J, Hou X, Meng W, Wu B, Su Y, Zhang H, Zheng W *,Fang Y*.Effects of dietaryLactobacillus helveticuson the growth rate, disease resistance and intestinal health of pond loach (Misgurnus anguillicaudatus) [J]. Aquaculture, 2021, 544: 737038. (SCI 1区, IF 5.135).
[13]Wu X, Sibtain A, Cui X, Hang J, Wang S, Liu S,Fang Y*.Expression and characterization of a novel organic solvent tolerant protease fromBacillus sphaericusDS11. Preparative Biochemistry Biotechnology, 2021, 51(1): 28–34. (SCI 4区, IF 2.30).
[14]Liu S, Sibtain A⁎, Zhang C, Liu T, Shao C,Fang Y*. Diversity and antimicrobial activity of culturable fungi associated with sea anemoneAnthopleura xanthogrammica. Electronic Journal of Biotechnology. 2020, 44: 41-46 (SCI 4区, IF 2.47).
[15]Chai J, Hang J, Zhang C, Yang J, Wang S, Liu S*,Fang*Y. Purification and characterization of chitin deacetylase active on insoluble chitin from Nitratireductor aquimarinus MCDA3-3. International Journal of Biological Macromolecules. 2020, 152: 922-929 (SCI 2区, IF 4.04).
[16]Liu S, Sibtain A*,Fang Y*.Cloning, Expression and Characterization of a Novel α‑Amylase fromSalinispora arenicolaCNP193. The Protein Journal. 2019, 38: 716–722. (SCI 4区, IF 1.22).
[17]Ye W, Ma H, Liu L, Yu J, Lai J,Fang Y*,Fan Y*. Biocatalyzed route for the preparation of surface-deacetylated chitin nanofibers. Green chemistry, 2019, 21, 3143-3151 (SCI 1区, IF 9.43).
[18]Gu Z, Lai J, Hang J, Zhang C, Wang S, Jiao Y, Liu* S,Fang Y*.Theoretical and experimental studies on the conformational changes of organic solvent-stable protease fromBacillus sphaericusDS11 in methanol/water mixtures. International Journal of Biological Macromolecules, 2019, 128: 603–609 (SCI 2区, IF 4.04).
[19]黄怡忱,华梓延,张格文,刘姝侯晓月,池可心,杨光,周翔,房耀维*.嗜热链球菌FUA329发酵制备石榴汁酸奶的工艺优化及其品质特性.食品工业科技, 2024, 45 (21): 174-181 (EI收录).
[20]陆笑月,华梓延,吴晴,吴浩,刘姝,杨光,侯晓月,房耀维*.小黄鱼酶解产物促嗜热链球菌FUA329增殖和抗氧化性研究[J].食品工业科技, 2024, 45 (18): 138-145 (EI收录).
三、近五年承担科研项目
1.江苏海洋生物资源创新中心，2023年度技术攻关和成果转化合作项目，基于海洋酶制剂的甲壳废弃物高值化利用关键技术研究，JOUH23604，2023-1至2024-12，57万元，在研，主持；
2.企业横向 转化鞣花酸生成尿石素A菌株的筛选及初步应用，JOUH21336, 2022-7至2023-06，100万元，在研，主持；
3.江苏省教育厅，江苏省高等学校自然科学研究重大项目，20KJA550001，构巢曲霉几丁质脱乙酰酶抑制剂的筛选及分子机制研究，2020-2023，30万元，完成，主持；
4.江苏省组织部，江苏省第五期“ 333工程”科研项目，BRA2019243，基于理性设计提高海洋Bacillus sphaericus蛋白酶有机溶剂耐受性，2019-01至2021-12，完成，主持；
5.国家自然科学基金面上项目：海洋Bacillus sphaericus蛋白酶有机溶剂耐受性的分子机制研究（31772016），2018-2021，78万元，结题，主持；
6.江苏省省海洋科技创新项目：水产养殖网箱的污染防治及污染物快速清除关键技术研究( HY2018-10)，2018-2020，25万元，结题，主持。
